PDP2
Function
Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA (By similarity). Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17 (By similarity).
Sequence Similarities
Belongs to the PP2C family.
Cellular localization
- Mitochondrion
Alternative names
KIAA1348, PDP2, PDP 2, Pyruvate dehydrogenase phosphatase catalytic subunit 2, PDPC 2