PDYN
Function
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin (By similarity).
Leumorphin has a typical opioid activity and may have anti-apoptotic effect.
Involvement in disease
Spinocerebellar ataxia 23
SCA23
Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Sequence Similarities
Belongs to the opioid neuropeptide precursor family.
Cellular localization
- Secreted
Alternative names
Proenkephalin-B, Beta-neoendorphin-dynorphin, Preprodynorphin, PDYN