Pdyn
Function
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin (By similarity).
Leumorphin has a typical opioid activity and may have anti-apoptotic effect.
Post-translational modifications
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Sequence Similarities
Belongs to the opioid neuropeptide precursor family.
Cellular localization
- Secreted
Alternative names
Proenkephalin-B, Beta-neoendorphin-dynorphin, Preprodynorphin