The RING-type zinc finger domain is required for E3 ligase activity.
E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.
Protein modification; protein ubiquitination.
Auto-ubiquitinated.
Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.
KIAA1095, LNX3, SEMCAP3, PDZRN3, E3 ubiquitin-protein ligase PDZRN3, Ligand of Numb protein X 3, PDZ domain-containing RING finger protein 3, RING-type E3 ubiquitin transferase PDZRN3, Semaphorin cytoplasmic domain-associated protein 3, Protein SEMACAP3
Proteins
Immunology & Infectious Disease
119596Da
We found 1 product in 1 category