PDZRN3
Domain
The RING-type zinc finger domain is required for E3 ligase activity.
Function
E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Auto-ubiquitinated.
Tissue Specificity
Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.
Cellular localization
- Synapse
- Cytoplasm
- Localizes to the postsynaptic region of neuromuscular junctions.
Alternative names
KIAA1095, LNX3, SEMCAP3, PDZRN3, E3 ubiquitin-protein ligase PDZRN3, Ligand of Numb protein X 3, PDZ domain-containing RING finger protein 3, RING-type E3 ubiquitin transferase PDZRN3, Semaphorin cytoplasmic domain-associated protein 3, Protein SEMACAP3