PEAR1

Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity).

Phosphorylated in the intracellular domain on tyrosine residues (PubMed:15851471). Phosphorylated on tyrosine residues by SRC (PubMed:15851471). Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation (PubMed:15851471). Tyrosine phosphorylation enhanced its association with SHC1 and SHC2 (PubMed:15851471). Phosphorylated when in the presence of SVEP1 (PubMed:36792666).

Belongs to the MEGF family.

Expressed in umbilical vein endothelial cells and platelets (at protein level) (PubMed:15851471, PubMed:36792666). Expressed in coronary artery smooth muscle cells (at protein level) (PubMed:36792666). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion (PubMed:15851471). Expressed in umbilical artery endothelial cells, megakaryocytes, osteoblasts, coronary muscle and erythroid cells (PubMed:15851471).

• Cell membrane
• Single-pass membrane protein
• Cell projection
• Lamellipodium
• Detected on the cell surface in resting platelets.

MEGF12, PEAR1, Platelet endothelial aggregation receptor 1, hPEAR1, Multiple epidermal growth factor-like domains protein 12, Multiple EGF-like domains protein 12

• entrezGene:375033
• omim:610278
• swissprot:Q5VY43

Proteins

Immunology & Infectious Disease

110666Da