PEP1
Domain
The lumenal domain contains two regions of approximately 650 AA that exhibit 20% identity. The cytoplasmic domain serves as a Golgi retention/recycling signal.
Function
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. May execute multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment. Binds the Golgi-modified P2 form of CPY, and this interaction is dependent on the presence of an intact CPY vacuolar protein sorting signal.
Sequence Similarities
Belongs to the VPS10-related sortilin family.
Cellular localization
- Golgi apparatus
- trans-Golgi network membrane
- Single-pass type I membrane protein
- Prevacuolar compartment membrane
- Single-pass type I membrane protein
- Cycles between the Golgi apparatus and the prevacuolar compartments.
Alternative names
VPS10, VPT1, YBL017C, YBL03.22, YBL0302, PEP1, Vacuolar protein sorting/targeting protein VPS10, Carboxypeptidase Y receptor, Carboxypeptidase Y-deficient protein 1, Sortilin VPS10, Vacuolar carboxypeptidase sorting receptor VPS10, Vacuolar protein sorting-associated protein 10, Vacuolar protein-targeting protein 1, CPY receptor