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PRD

Function

Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.

Involvement in disease

Prolidase deficiency

PD

A multisystem disorder associated with massive iminodipeptiduria and lack of or reduced prolidase activity in erythrocytes, leukocytes, or cultured fibroblasts. Clinical features include skin ulcers, developmental delay, recurrent infections, and a characteristic facies.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.

Alternative names

  • Xaa-Pro dipeptidase
  • X-Pro dipeptidase
  • Imidodipeptidase
  • Peptidase D
  • Proline dipeptidase
  • Prolidase
  • PEPD
  • PRD

Target type

Proteins

Molecular weight

54548Da