PEX11B
Function
Involved in peroxisomal proliferation (PubMed:9792670). May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).
Involvement in disease
Peroxisome biogenesis disorder 14B
PBD14B
An autosomal recessive peroxisome biogenesis disorder characterized clinically by mild intellectual disability, congenital cataracts, progressive hearing loss, and polyneuropathy. Additionally, recurrent migraine-like episodes following mental stress or physical exertion, not a common feature in peroxisome disorders, are observed.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the peroxin-11 family.
Cellular localization
- Peroxisome membrane
- Single-pass membrane protein
Alternative names
Peroxisomal membrane protein 11B, Peroxin-11B, Peroxisomal biogenesis factor 11B, Protein PEX11 homolog beta, PEX11-beta, PEX11B