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Pf4

Function

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity).

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Cellular localization

  • Secreted

Alternative names

  • Platelet factor 4
  • PF-4
  • C-X-C motif chemokine 4
  • Pf4
  • Cxcl4
  • Scyb4

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

11243Da