PFAS
Function
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
Pathway
Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.
Sequence Similarities
In the N-terminal section; belongs to the FGAMS family.
Cellular localization
- Cytoplasm
Alternative names
KIAA0361, PFAS, Phosphoribosylformylglycinamidine synthase, FGAM synthase, FGAMS, Formylglycinamide ribonucleotide amidotransferase, Formylglycinamide ribotide amidotransferase, Phosphoribosylformylglycineamide amidotransferase, FGAR amidotransferase, FGAR-AT