Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Belongs to the profilin family.
Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.
Profilin-2, Profilin II, PFN2
Proteins
Immunology & Infectious Disease
15046Da
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