PFN2
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Sequence Similarities
Belongs to the profilin family.
Tissue Specificity
Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.
Cellular localization
- Cytoplasm
- Cytoskeleton
Alternative names
Profilin-2, Profilin II, PFN2