PGAM1

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202).

Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme.

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Expressed in the liver and brain. Not found in the muscle.

PGAMA, CDABP0006, PGAM1, Phosphoglycerate mutase 1, BPG-dependent PGAM 1, Phosphoglycerate mutase isozyme B, PGAM-B

• entrezGene:5223
• omim:172250
• swissprot:P18669

Proteins

Immunology & Infectious Disease

28804Da