PGF
GeneName
PGF
Summary
PGF, also known as PlGF or placenta growth factor, is a 25 kDa secreted protein that plays a significant role in angiogenesis and the regulation of vascular development. It is primarily expressed in the extracellular region and is involved in various biological processes, including cell differentiation and cell-cell signalling. PGF acts as a chemoattractant and growth factor, binding to vascular endothelial growth factor receptors, which mediates its effects on endothelial cells. Additionally, it is implicated in the response to hypoxia and promotes mast cell chemotaxis, contributing to inflammatory responses and tissue repair.
Importance
PGF is relevant to: - Angiogenesis and tissue vascularisation, making it important in developmental biology and wound healing - Tumour biology, as it can influence tumour growth and metastasis through its effects on blood vessel formation - Cardiovascular diseases, given its role in regulating vascular integrity and response to hypoxic conditions - Allergic responses and asthma, due to its involvement in mast cell chemotaxis and inflammatory pathways
Top Products
For researchers investigating PGF, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-PLGF antibody (ab196666), which has garnered 14 citations and is highly regarded for its performance in both Western blotting (WB) and immunohistochemistry (IHC). This antibody is a trusted choice for those looking to study PGF in various contexts. Additionally, we offer the recombinant antibody, Anti-PLGF antibody [EPR2802(2)] (ab140639), which is validated for use in Western blotting (WB). This recombinant option provides the advantage of batch-to-batch consistency, making it an ideal choice for researchers who require reliable results in their experiments. The Anti-PLGF antibody [EPR2802(2)] ELISA Kit (ab140639), supported by 3 citations, is an excellent option for researchers looking to accurately measure PGF levels in their samples.
Abcam Product Citation Summary
The data indicates that PGF is being studied in the context of human bone marrow-derived mesenchymal stem cells, particularly focusing on its secretion. This suggests a potential role of PGF in stem cell biology and its implications in regenerative medicine.
Abcam Product Citation Table
Domain
Isoform PlGF-2 contains a basic insert which acts as a cell retention signal.
Function
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the PDGF/VEGF growth factor family.
Tissue Specificity
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
Cellular localization
- Secreted
- The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
Alternative names
PGFL, PLGF, PGF, Placenta growth factor, PlGF
Database links
swissprot:P49763 entrezGene:5228 omim:601121
Other research areas
- Immuno-oncology