PGM5
Developmental stage
In the developing aorta, expressed at low levels in 10-12 week old fetuses. Levels increase progressively in 24 week fetus, 6 month old child and 1.5 year old child aortic smooth muscle, reaching a maximum at maturity.
Function
Component of adherens-type cell-cell and cell-matrix junctions (PubMed:8175905). Has no phosphoglucomutase activity in vitro (PubMed:8175905).
Sequence Similarities
Belongs to the phosphohexose mutase family.
Tissue Specificity
Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component. Low levels are present in liver, kidney, skin and brain (at protein level).
Cellular localization
- Cell junction
- Adherens junction
- Cytoplasm
- Cytoskeleton
- Cell membrane
- Sarcolemma
- Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments.
Alternative names
PGMRP, PGM5, Phosphoglucomutase-like protein 5, Aciculin, Phosphoglucomutase-related protein, PGM-RP