PGR

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Phosphorylation of Ser-529 is sharply increased upon progesterone treatment, whereas phosphorylation of Ser-210 and Ser-259 is modestly induced by progesterone.

Ubiquitinated. Ubiquitination is increased by progesterone and represses sumoylation at the same site (By similarity).

Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-385, the main site of sumoylation, is repressed by ubiquitination on the same site (By similarity).

Belongs to the nuclear hormone receptor family. NR3 subfamily.

Oviduct and bursa of Fabricius.

• Nucleus
• Cytoplasm
• Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity).
• Isoform A
• Nucleus
• Cytoplasm
• Mainly nuclear.

NR3C3, Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3

• swissprot:P07812

Proteins

Immunology & Infectious Disease