PGR
Domain
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
Post-translational modifications
Phosphorylation of Ser-529 is sharply increased upon progesterone treatment, whereas phosphorylation of Ser-210 and Ser-259 is modestly induced by progesterone.
Ubiquitinated. Ubiquitination is increased by progesterone and represses sumoylation at the same site (By similarity).
Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-385, the main site of sumoylation, is repressed by ubiquitination on the same site (By similarity).
Sequence Similarities
Belongs to the nuclear hormone receptor family. NR3 subfamily.
Tissue Specificity
Oviduct and bursa of Fabricius.
Cellular localization
- Nucleus
- Cytoplasm
- Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity).
- Isoform A
- Nucleus
- Cytoplasm
- Mainly nuclear.
Alternative names
NR3C3, Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3