PGRMC2
Domain
The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161.
Function
Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).
Sequence Similarities
Belongs to the cytochrome b5 family. MAPR subfamily.
Tissue Specificity
Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472). Detected in urine (at protein level) (PubMed:37453717).
Cellular localization
- Membrane
- Single-pass membrane protein
- Nucleus envelope
- Endoplasmic reticulum
- Secreted
Alternative names
DG6, PMBP, PGRMC2, Membrane-associated progesterone receptor component 2, Progesterone membrane-binding protein, Steroid receptor protein DG6