PGRMC2

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161.

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).

Belongs to the cytochrome b5 family. MAPR subfamily.

Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472). Detected in urine (at protein level) (PubMed:37453717).

• Membrane
• Single-pass membrane protein
• Nucleus envelope
• Endoplasmic reticulum
• Secreted

DG6, PMBP, PGRMC2, Membrane-associated progesterone receptor component 2, Progesterone membrane-binding protein, Steroid receptor protein DG6

• entrezGene:10424
• omim:607735
• swissprot:O15173

Proteins

Immunology & Infectious Disease

23818Da