PHF23
Domain
The PHD-type zinc-finger domain is required for interaction with LRSAM1 and negative regulation of autophagy.
Function
Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria.
Involvement in disease
A chromosomal aberration involving PHF23 is found in a patient with acute myeloid leukemia (AML). Translocation t(11;17)(p15;p13) with NUP98.
Sequence Similarities
Belongs to the PHF23 family.
Tissue Specificity
Widely expressed in human tissues and various cell lines.
Cellular localization
- Nucleus
- Cytoplasm
- Mainly present in the nucleus and part in the cytoplasm.
Alternative names
PHD finger protein 23, PDH-containing protein JUNE-1, PHF23