PIK3R3

Function

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Sequence Similarities

Belongs to the PI3K p85 subunit family.

Tissue Specificity

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.

Alternative names

Phosphatidylinositol 3-kinase regulatory subunit gamma, PI3-kinase regulatory subunit gamma, PI3K regulatory subunit gamma, PtdIns-3-kinase regulatory subunit gamma, Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma, p55PIK, PI3-kinase subunit p55-gamma, PtdIns-3-kinase regulatory subunit p55-gamma, PIK3R3

Database links

swissprot:Q92569 entrezGene:5290 entrezGene:8503 swissprot:P42336 omim:606076 omim:171834