PIK3R6
Function
Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.
Cellular localization
- Cytoplasm
- Cell membrane
- Peripheral membrane protein
- Translocated to the plasma membrane in a Ras-dependent manner.
Alternative names
C17orf38, PIK3R6, Phosphoinositide 3-kinase regulatory subunit 6, Phosphoinositide 3-kinase gamma adapter protein of 87 kDa, p84 PI3K adapter protein, p87 PI3K adapter protein, p84 PIKAP, p87PIKAP