PIMREG
Developmental stage
Regulated in a cell-cycle dependent manner, with lowest levels in quiescent cells or at G1 phase. Progressive up-regulation starting at S phase and peaking at G2 and G2/M phases, followed by a drastic drop as cells exit mitosis (at protein level).
Domain
The N-terminal destruction box 2 (D-box 2) is required for APC/C ubiquitination and proteasomal degradation.
Function
During mitosis, may play a role in the control of metaphase-to-anaphase transition.
Post-translational modifications
Ubiquitinated by the anaphase-promoting complex/cyclosome (APC/C) complex in the presence of FZR1, leading to its degradation by the proteasome during mitotic exit. However, degradation is not essential for normal mitotic progression within a single cell cycle.
Tissue Specificity
Expressed in thymus (at protein level). Detected in spleen, colon, ovary and small intestines.
Cellular localization
- Nucleus
- Nucleus
- Nucleolus
- Partially localizes to the nucleolus.
Alternative names
CATS, FAM64A, RCS1, PIMREG, Protein PIMREG, CALM-interactor expressed in thymus and spleen, PICALM-interacting mitotic regulator, Regulator of chromosome segregation protein 1