PINX1
Domain
The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.
The TBM domain mediates interaction with TERF1.
Function
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
Post-translational modifications
Cleaved by enterovirus protease 3C to promote apoptosis.
Sequence Similarities
Belongs to the PINX1 family.
Tissue Specificity
Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
Cellular localization
- Nucleus
- Nucleus
- Nucleolus
- Chromosome
- Telomere
- Chromosome
- Centromere
- Kinetochore
- Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
Alternative names
LPTL, LPTS, PINX1, PIN2/TERF1-interacting telomerase inhibitor 1, Liver-related putative tumor suppressor, Pin2-interacting protein X1, Protein 67-11-3, TRF1-interacting protein 1