PIR
Function
Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).
Pathway
Flavonoid metabolism; quercetin degradation.
Sequence Similarities
Belongs to the pirin family.
Tissue Specificity
Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver.
Cellular localization
- Nucleus
- Cytoplasm
- Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.
Alternative names
Pirin, Probable quercetinase, PIR