PITPNM1
Function
Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914).
Post-translational modifications
Phosphorylated on multiple sites by CDK1 at the onset of mitosis. Phosphorylation facilitates dissociation from the Golgi complex and is required for interaction with PLK1.
Phosphorylated on threonine residues upon treatment with oleic acid.
Phosphorylated on tyrosine residues by PTK2B.
Sequence Similarities
Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- Golgi apparatus
- Golgi stack membrane
- Peripheral membrane protein
- Endoplasmic reticulum membrane
- Peripheral membrane protein
- Lipid droplet
- Cleavage furrow
- Midbody
- Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets (PubMed:12225667). Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (PubMed:15125835).
Alternative names
DRES9, NIR2, PITPNM, PITPNM1, Membrane-associated phosphatidylinositol transfer protein 1, Drosophila retinal degeneration B homolog, Pyk2 N-terminal domain-interacting receptor 2, PITPnm 1, NIR-2