PKD1L3

Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.

Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity.

Belongs to the polycystin family.

Highly expressed in placenta, weakly in heart and lung.

• Cell membrane
• Multi-pass membrane protein
• Interaction with PKD2L1 is required for localization to the cell membrane.

Polycystin-1-like protein 3, Polycystin-1L3, PC1-like 3 protein, Polycystic kidney disease protein 1-like 3, PKD1L3

• entrezGene:342372
• omim:607895
• swissprot:Q7Z443

Proteins

Immunology & Infectious Disease

195894Da