PKP4
Function
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
Sequence Similarities
Belongs to the beta-catenin family.
Tissue Specificity
Expressed in salivary glands (at protein level) (PubMed:30479852). Expressed in arrector pili muscle (at protein level) (PubMed:29034528).
Cellular localization
- Cell junction
- Desmosome
- Cytoplasm
- Cytoskeleton
- Spindle
- Midbody
- Cell membrane
- Peripheral membrane protein
- Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.
Alternative names
Plakophilin-4, p0071, PKP4