PLA2G4B
Domain
The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
Function
Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling.
Isoform 3
Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines.
Isoform 5
Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids.
Tissue Specificity
Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas.
Cellular localization
- Isoform 3
- Cytoplasm
- Cytosol
- Mitochondrion membrane
- Peripheral membrane protein
- Early endosome membrane
- Peripheral membrane protein
- Translocates to membrane vesicles in a calcium-dependent fashion.
- Isoform 5
- Cytoplasm
- Cytosol
Alternative names
Cytosolic phospholipase A2 beta, cPLA2-beta, Lysophospholipase A1 group IVB, Phospholipase A2 group IVB, PLA2G4B