Platelet glycoprotein V
Function
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
Post-translational modifications
The N-terminus is blocked.
Tissue Specificity
Platelets and megakaryocytes.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD42d, Platelet glycoprotein V, GPV, Glycoprotein 5, GP5