PLAUR

Acts as a receptor for urokinase plasminogen activator (PubMed:15677461). Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

• Cell membrane
• Cell projection
• Invadopodium membrane
• Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.
• Isoform 1
• Cell membrane
• Lipid-anchor
• GPI-anchor
• Isoform 2
• Secreted

CD87, MO3, UPAR, PLAUR, Urokinase plasminogen activator surface receptor, U-PAR, uPAR, Monocyte activation antigen Mo3

• entrezGene:5329
• omim:173391
• swissprot:Q03405

Proteins

Immunology & Infectious Disease

36978Da