PLCD3
Domain
The C2 domain is a Ca(2+)-dependent membrane-targeting module.
The PH domain mediates interaction with the surface membrane by binding to PIP2.
Function
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity).
Tissue Specificity
Present in corneal epithelial cells (at protein level).
Cellular localization
- Membrane
- Peripheral membrane protein
- Cytoplasm
- Cleavage furrow
- Localizes at the cleavage furrow during cytokinesis.
Alternative names
KIAA1964, PLCD3, Phosphoinositide phospholipase C-delta-3, Phospholipase C-delta-3, PLC-delta-3