PLCH2
Function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:18361507). This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).
Tissue Specificity
Expressed in retina and kidney.
Cellular localization
- Cytoplasm
- Cell membrane
- Localized predominantly at the plasma membrane.
Alternative names
KIAA0450, PLCL4, PLCH2, Phosphoinositide phospholipase C-eta-2, Phosphoinositide phospholipase C-like 4, Phospholipase C-eta-2, PLC-L4, Phospholipase C-like protein 4, PLC-eta2