PLD4
Function
5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia.
Post-translational modifications
Highly N-glycosylated.
Sequence Similarities
Belongs to the phospholipase D family.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass type II membrane protein
- Golgi apparatus
- trans-Golgi network membrane
- Single-pass type II membrane protein
- Nucleus
- Early endosome
- Cytoplasmic vesicle
- Phagosome
- Activation of microglia induces translocation of PLD4 from the nucleus to the phagosomes.
Alternative names
C14orf175, UNQ2488/PRO5775, PLD4, 5'-3' exonuclease PLD4, Choline phosphatase 4, Phosphatidylcholine-hydrolyzing phospholipase D4, Phospholipase D family member 4, Phospholipase D4, PLD 4