PLEKHA1

Binds to membranes enriched in PtdIns3,4P2 via the C-terminal PH domain.

Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.

Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon.

• Cytoplasm
• Cell membrane
• Peripheral membrane protein
• Nucleus
• Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.

TAPP1, PLEKHA1, Pleckstrin homology domain-containing family A member 1, PH domain-containing family A member 1, Tandem PH domain-containing protein 1, TAPP-1

• entrezGene:59338
• omim:607772
• swissprot:Q9HB21

Proteins

Immunology & Infectious Disease

45553Da