PLEKHA8
Domain
The PH domain of FAPPS binds the small GTPase ARF1 and phosphatidylinositol-4-phosphate (PtdIns4P) with high selectivity, and is required for recruitment of FAPPs to the trans-Golgi network (TGN).
Function
Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
Tissue Specificity
Expressed in kidney cell lines.
Cellular localization
- Golgi apparatus
- trans-Golgi network membrane
- Membrane
- Peripheral membrane protein
- Binds through its PH domain to PtdIns(4)P and ARF1, and subsequently localizes to TGN exit sites.
Alternative names
FAPP2, PLEKHA8, Pleckstrin homology domain-containing family A member 8, PH domain-containing family A member 8, Phosphatidylinositol-four-phosphate adapter protein 2, Serologically defined breast cancer antigen NY-BR-86, FAPP-2, Phosphoinositol 4-phosphate adapter protein 2, hFAPP2