PLEKHG3
Function
Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Colocalizes with actin at the leading edge of polarized cells.
Alternative names
KIAA0599, PLEKHG3, Pleckstrin homology domain-containing family G member 3, PH domain-containing family G member 3