PLEKHG4B
Domain
Subjects to autoinhibition, mediated by the N-terminal domain.
Function
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. Plays a role in actin cytoskeletal remodeling in the late stage of cell-cell junction formation by regulating the contractility of actin filaments, which prompts the conversion from 'open' to 'closed' junctions.
Cellular localization
- Basal cell membrane
- Cell junction
- Nucleus
- Cytoplasm
- Located at the basal plane of cell-cell junctions (PubMed:33310911). Intracellular Ca(2+) concentration is a key factor in regulating PLEKHG4B localization; it diffusely distributes in the cytoplasm under low Ca(2+) conditions, localizes to the basal membrane under normal Ca(2+) conditions, and accumulates at the cell-cell junction under higher Ca(2+) conditions (PubMed:38088892).
Alternative names
KIAA1909, PLEKHG4B, Pleckstrin homology domain-containing family G member 4B, PH domain-containing family G member 4B