PLEKHN1
Domain
Both PH domains are essential for its mitochondrial localization.
Function
Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1 (PubMed:29180010). Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS) (PubMed:18191643). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells (By similarity) (PubMed:29531808).
Post-translational modifications
Phosphorylation is essential for its mitochondrial localization and regulates its interaction with C1QBP.
Tissue Specificity
Ubiquitous (PubMed:18191643). Epressed in several cancer cell lines of differing origin (PubMed:29531808).
Cellular localization
- Cell membrane
- Lipid-anchor
- Mitochondrion
- Mitochondrion membrane
- Interaction with C1QBP and phosphorylation is essential for its mitochondrial localization. Localizes on the microtubule in the form of small granules.
Alternative names
CLPABP, PLEKHN1, Pleckstrin homology domain-containing family N member 1, PH domain-containing family N member 1, Cardiolipin and phosphatidic acid-binding protein