Plin1
Function
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.
Post-translational modifications
Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity).
Sequence Similarities
Belongs to the perilipin family.
Cellular localization
- Endoplasmic reticulum
- Lipid droplet
- Lipid droplet surface-associated.
Alternative names
Peri, Plin, Cnlp, Camp, Cramp, Perilipin-1, Lipid droplet-associated protein, Perilipin A