PLIN2
Function
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.
Post-translational modifications
Acylated; primarily with C14, C16 and C18 fatty acids.
Phosphorylation at Tyr-232 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.
Sequence Similarities
Belongs to the perilipin family.
Tissue Specificity
Milk lipid globules.
Cellular localization
- Membrane
- Peripheral membrane protein
- Lipid droplet
Alternative names
ADFP, PLIN2, Perilipin-2, Adipophilin, Adipose differentiation-related protein, ADRP