PLIN3
Function
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177).
Post-translational modifications
Phosphorylation at Tyr-251 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.
Sequence Similarities
Belongs to the perilipin family.
Cellular localization
- Lipid droplet
- Endosome membrane
- Peripheral membrane protein
- Cytoplasmic side
- Cytoplasm
- Membrane associated on endosomes (PubMed:15545278). Detected in the envelope and the core of lipid bodies and in lipid sails (PubMed:15545278).
Alternative names
M6PRBP1, TIP47, PLIN3, Perilipin-3, 47 kDa mannose 6-phosphate receptor-binding protein, Cargo selection protein TIP47, Mannose-6-phosphate receptor-binding protein 1, Placental protein 17, 47 kDa MPR-binding protein, PP17