Perilipin 3/TIP47

Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177).

Phosphorylation at Tyr-251 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.

Belongs to the perilipin family.

• Lipid droplet
• Endosome membrane
• Peripheral membrane protein
• Cytoplasmic side
• Cytoplasm
• Membrane associated on endosomes (PubMed:15545278). Detected in the envelope and the core of lipid bodies and in lipid sails (PubMed:15545278).

M6PRBP1, TIP47, PLIN3, Perilipin-3, 47 kDa mannose 6-phosphate receptor-binding protein, Cargo selection protein TIP47, Mannose-6-phosphate receptor-binding protein 1, Placental protein 17, 47 kDa MPR-binding protein, PP17

• entrezGene:10226
• omim:602702
• swissprot:O60664

Proteins

Neuroscience

47075Da