Plin3
Function
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.
Post-translational modifications
Phosphorylation at Tyr-255 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.
Sequence Similarities
Belongs to the perilipin family.
Cellular localization
- Lipid droplet
- Endosome membrane
- Peripheral membrane protein
- Cytoplasmic side
- Cytoplasm
- Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails.
Alternative names
M6prbp1, Tip47, Plin3, Perilipin-3, Cargo selection protein TIP47, Mannose-6-phosphate receptor-binding protein 1