Plp1
Function
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
Involvement in disease
Defects in Plp1 are the cause of the dysmyelinating diseases Jimpy and Rumpshaker (rsh).
Sequence Similarities
Belongs to the myelin proteolipid protein family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Myelin membrane
- Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.
Alternative names
Plp, Plp1, Myelin proteolipid protein, PLP, Lipophilin