PLSCR4
Domain
The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
Function
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Sequence Similarities
Belongs to the phospholipid scramblase family.
Tissue Specificity
Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes.
Cellular localization
- Membrane
- Single-pass type II membrane protein
Alternative names
GIG43, PLSCR4, Phospholipid scramblase 4, PL scramblase 4, Ca(2+)-dependent phospholipid scramblase 4, Cell growth-inhibiting gene 43 protein, TRA1