PLVAP/PV-1

Expressed in embryo at 7 dpc. Expressed in the brain vasculature at 12 up to 16 dpc, whereupon it disappears.

Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.

Expressed in lung, kidney, spleen, heart, muscle, eye, pancreas, thyroid, thymus, submaxillary gland, prostate, epididymis, uterus and liver.

• Cell membrane
• Single-pass type II membrane protein
• Membrane
• Caveola
• Single-pass type II membrane protein
• Cytoplasm
• Perinuclear region
• Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region.

Pv1, Plasmalemma vesicle-associated protein, MECA-32 antigen, Plasmalemma vesicle protein 1, PV-1

• swissprot:Q91VC4

Proteins

Immunology & Infectious Disease