Plxna1
Function
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis (PubMed:16715077).
Sequence Similarities
Belongs to the plexin family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
Kiaa4053, Plxna1, Plexin-A1, Plex 1, Plexin-1