PLXNA4
Function
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Sequence Similarities
Belongs to the plexin family.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
KIAA1550, PLXNA4A, PLXNA4B, UNQ2820/PRO34003, PLXNA4, Plexin-A4