PMF1

Function

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.

Tissue Specificity

Highest levels of expression in heart and skeletal muscle, with significant levels expressed in kidney and liver.

Cellular localization

• Nucleus
• Chromosome
• Centromere
• Kinetochore
• Associated with the kinetochore.

Alternative names

Polyamine-modulated factor 1, PMF-1, PMF1

Database links

swissprot:Q6P1K2 entrezGene:100527963 entrezGene:11243 omim:609176