PNC1
Function
Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate.
Pathway
Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.
Sequence Similarities
Belongs to the isochorismatase family.
Cellular localization
- Cytoplasm
- Nucleus
- Peroxisome
- Concentrates in peroxisomes (PubMed:12736687).
Alternative names
YGL037C, PNC1, Nicotinamidase, Nicotinamide deamidase, NAMase