Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate.
Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.
Belongs to the isochorismatase family.
YGL037C, PNC1, Nicotinamidase, Nicotinamide deamidase, NAMase
Proteins
Immunology & Infectious Disease
24993Da
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