PNLDC1
Function
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (By similarity). Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs (PubMed:34347949).
Involvement in disease
Spermatogenic failure 57
SPGF57
An autosomal recessive male infertility disorder characterized by non-obstructive azoospermia, due to error-prone meiosis and spermatogenic arrest at the late pachytene stage.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the CAF1 family.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass membrane protein
- Localizes mainly in the endoplasmic reticulum (PubMed:27515512).
Alternative names
Poly(A)-specific ribonuclease PNLDC1, PARN-like domain-containing protein 1, Poly(A)-specific ribonuclease domain-containing protein 1, HsPNLDC1, PNLDC1