Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
Pancreatic lipase deficiency
PNLIPD
An autosomal recessive disorder characterized by exocrine pancreatic failure. Clinical findings include oily/greasy stools from infancy or early childhood, absence of discernible pancreatic disease, and significantly decreased pancreatic lipolytic activity.
None
The disease is caused by variants affecting the gene represented in this entry.
Belongs to the AB hydrolase superfamily. Lipase family.
Pancreatic triacylglycerol lipase, PL, PTL, Pancreatic lipase, PNLIP
Proteins
Immunology & Infectious Disease
51157Da
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