PNPLA4
Function
Has abundant triacylglycerol lipase activity (PubMed:15364929, PubMed:16150821, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Additionally possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17603008).
Involvement in disease
Defects in PNPLA4 may play a role in mitochondrial disorders characterized by complex IV deficiency.
Tissue Specificity
Expressed in all tissues examined, including heart, brain, placenta, lung, liver, muscle, kidney, pancreas and spleen.
Cellular localization
- Mitochondrion
Alternative names
DXS1283E, GS2, PNPLA4, Patatin-like phospholipase domain-containing protein 4, Calcium-independent phospholipase A2-eta, Protein GS2, iPLA2-eta